Valestra 2mg Tablet

Hypoestrogenism:

• Definition: Hypoestrogenism refers to a condition characterized by lower-than-normal levels of estrogen, a key female sex hormone.
• Significance: Abnormalities in estrogen levels can lead to various health issues, including infertility, bone loss, and lipid (fat) metabolism abnormalities.
• Impact: Hypoestrogenism is associated with conditions where estrogen production or activity is diminished, affecting reproductive health, bone density, and lipid balance.

Hormone Replacement Therapy (HRT):

• Purpose: HRT is a medical treatment designed to alleviate symptoms associated with menopause, which occurs when natural hormone levels decline.
• Hormones Involved: Typically involves replacing estrogen and, in some cases, progestin (a synthetic form of progesterone) to balance hormonal levels.
• Symptom Relief: HRT is used to manage symptoms like hot flashes, vaginal dryness, and mood changes that occur during menopause.
• Bone Health: In postmenopausal women, HRT may also help prevent osteoporosis by addressing the decline in estrogen levels.

Osteoporosis:

• Definition: Osteoporosis is a medical condition characterized by weakened and porous bones, making them more susceptible to fractures.
• Cause: The disease results from an imbalance between the formation of new bone and the resorption of existing bone.
• Risk Factors: Aging, hormonal changes (such as decreased estrogen in menopause), and certain medical conditions contribute to the development of osteoporosis.
• Consequences: Fragile bones increase the risk of fractures, especially in the hip, spine, and wrist.

Uses:

Hormonal replacement therapy, Hypoestrogenism (estrogen deficiency), Osteoporosis (thinning of bones), Symptoms associated with menopause (itching, dryness in vagina, hot flushes)

How does Valestra 2mg Tablet work?

Valestra 2mg Tablet contains a precursor of ovarian hormones responsible for menstruation and reproduction in women. It replaces the natural Estradiol hormone in the body, helping maintain adequate hormone levels. This provides relief from vasomotor symptoms, such as hot flashes, in post-menopausal women.

Quick Suggestions:

• Regular Exercise and Physical Activity minimize hot flashes, Improve sleep, and strengthen bones with weight-bearing exercises.
• Include aerobics, yoga, and activities like tai chi for overall well-being.
• Wear loose clothes before bedtime.
• Sleep in a cool, well-ventilated room.
• Aim for a minimum of 8 hours of sleep.
• Avoid or limit caffeine-containing beverages, alcohol, and spicy foods, known triggers for hot flashes.
• Be stress-free to alleviate mood swings caused by hormonal fluctuations.
• Quitting smoking can Reduce hot flashes, and lower the risk of chronic conditions such as heart disease, stroke, and cancer.

Indications:

Valestra 2mg Tablet is indicated for the short-term treatment of climacteric complaints following the cessation of monthly bleeding. It is also prescribed for deficiency symptoms after oophorectomy or radiological castration for non-carcinomatous diseases. These symptoms include hot flashes, outbreaks of sweat, sleep disturbances, depressive moods, irritability, headaches, and dizziness.

Additionally, Valestra 2mg Tablet exhibits a favorable influence on bladder irritation, which is not uncommon during the climacteric period. It also addresses signs of cutaneous and mucosal involution, particularly in the genital region, which typically occurs with advancing age.

Pharmacology

Valestra 2mg Tablet is a naturally occurring estrogen. Estrogens play a crucial role in the development and maintenance of the female reproductive system and secondary sexual characteristics. They modulate the pituitary secretion of gonadotrophins, LH (luteinizing hormone), and FSH (follicle-stimulating hormone) through a negative feedback system.

Dosage & Administration:

Adult Dose Recommendations:

Vulvar and Vaginal Atrophy in Menopause:

• Dose: 1-2 mg
• Route: Oral
• Frequency: Once daily
• Duration: For 3 weeks, followed by 1 week off

Prevention of Osteoporosis:

• Dose: 0.5 mg
• Route: Oral
• Frequency: Once daily
• Duration: For 3 weeks, followed by 1 week off

Metastatic Breast Cancer:

• Dose: 10 mg
• Route: Oral
• Frequency: Every 8 hours (q8hr)
• Duration: For 3 months

Prostate Cancer:

• Dose: 1-2 mg
• Route: Oral
• Frequency: Every 8 hours (q8hr)
• Duration: At least 3 months (? indicates uncertainty)

Directions for Use of Valestra 2mg Tablet

• Take Valestra 2mg Tablet as advised by your physician.
• Swallow the medicine with a glass of water.
• Do not crush or chew the medicine.
• Your doctor will decide the correct dose and duration for you based on your age, body weight, and the specific disease condition being treated.

Interaction

• CYP1A2 and CYP3A4 Inducers: Concomitant use of CYP1A2 and CYP3A4 inducers such as aminoglutethimide, carbamazepine, phenobarbital, and rifampin may decrease the effects of estradiol.
• Enhancement of Effects: Estradiol may enhance the effects of hydrocortisone and prednisolone when used together.

Contraindications

• Hypersensitivity: Estradiol is contraindicated in individuals with hypersensitivity to any of its components.
• Undiagnosed Vaginal Bleeding: Contraindicated in cases of undiagnosed vaginal bleeding.
• Thrombophlebitis or Thromboembolic Disorders: Contraindicated in individuals with a history of thrombophlebitis or thromboembolic disorders.
• Breast Carcinoma: Contraindicated, except in selected patients being treated for metastatic disease.
• Estrogen-Dependent Tumor: Contraindicated in cases of estrogen-dependent tumors.
• Porphyria: Contraindicated in individuals with porphyria.
• Pregnancy: Contraindicated during pregnancy.

Pregnancy:

Therapy with Estradiol is not indicated for use during pregnancy. There is a lack of data regarding its use in pregnant women. Epidemiologic studies and meta-analyses have not found an increased risk of genital or nongenital birth defects, including cardiac anomalies and limb-reduction defects, following exposure to combined hormonal contraceptives (estrogen and progestins) before conception or during early pregnancy. However, the use of Estradiolduring pregnancy is not recommended

Lactation:

Estradiol therapy is not indicated for use in females of reproductive potential who are breastfeeding. Estrogens present in human milk can reduce milk production in breastfeeding females. While reduction can occur at any time, it is less likely to occur once breastfeeding is well-established.

Precautions & Warnings

Potential Risks and Effects:

• Increased blood pressure.
• Risk of venous thromboembolism.
• Increased risk of breast cancer.
• Benign hepatic adenoma.
• Endometrial cancer.
• Enlargement of preexisting uterine leiomyomata (fibroids).

Conditions Exacerbated by Fluid Retention:

• Certain medical conditions may worsen with fluid retention.

Other Conditions to Consider:

• Hypercalcemia (high calcium levels).
• Cerebrovascular disorders.
• Coronary artery disease.
• Gall bladder diseases.
• Lipid effects.
• Familial defects of lipoprotein metabolism.

The dosage may need to be reduced in individuals with hepatic impairment (liver-related issues).

• Caution is advised during lactation as the drug enters breast milk.
• The use of the drug is not recommended in children.

Storage Conditions

Store in a cool and dry place away from sunlight